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      當前位置:首頁 > 產品展示 > 藥靶細胞株 > 腫瘤免疫細胞株 > SIRPɑ/PD-1 Dual Effector Reporter Cell
      SIRPɑ/PD-1 Dual Effector Reporter Cell

      SIRPɑ/PD-1 Dual Effector Reporter Cell

      型    號: CBP74154
      報    價:

      SIRPɑ/PD-1 Dual Effector Reporter Cell

      CBP74154SIRPɑ/PD-1 Dual Effector Reporter Cell的詳細資料:

      I. Background
      SIRP alpha protein, or Signal regulatory proteinalpha (SIRP-α), also known as Tyrosine protein phosphatase non-receptor type substrate 1, CD172a, Bit, and MyD-1, GenBank Accession No. NM_080792, a.a. 27-370, with C-terminal Avi and His tags, MW 40.3 kDa*. This SIRP alpha protein acts as a receptor for CD47; a.a. 27-370 correspond to the extracellular portion of SIRP-α. *Note: SIRP-α is heavily glycosylated, resulting in higher molecular weight.

      The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes

      II. Introduction
      Expressed gene:SIRPɑ、PD-1
      Stability:32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
      Freeze Medium:90% FBS+10% DMSO
      Culture Medium:RPMI-1640+10%FBS+2ug/ml puromycin+5ug/ml blasticidin+200ug/ml hygromycin
      Mycoplasma Testing:Negative
      Storage:Liquid nitrogen
      Application(s):Functional(Report Gene) Assay
      III. Representative Data

      CBP74154+CBP74155 新.jpg

      Figure 1. Dose response of Blocking Antibodies in SIRPα/PD-1 Dual Effector Reporter Cells(C18) With CD47/PD-L1 Dual Target Cells.


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