公司名稱:南京康佰生物科技有限公司
地址:南京市雨花區長虹路222號
郵編:
電話:025-86880024
手機: 18066071954
聯系人: 蔣
傳真:
E-mail: zhangxiangwen@cobioer.com
地址:南京市雨花區長虹路222號
郵編:
電話:025-86880024
手機: 18066071954
聯系人: 蔣
傳真:
E-mail: zhangxiangwen@cobioer.com
CBP10519AI-Edigene® ABL1 p.T315I Reference Standard P的詳細資料:
CBP10519 | |
Format | Genomic DNA |
Description | ABL1 T315I is a gatekeeper mutation that lies within the hinge region of the protein kinase domain of the Abl1 protein (PMID: 18794843). T315I has been demonstrated to occur as a secondary resistance mutation and results in increased kinase activity and transformation in the context of BCR-ABL1 in cell culture (PMID: 11423618, PMID: 18794843, PMID: 27890928), and results in reduced catalytic efficiency (kcat/km) in an in vitro assay (PMID: 30684523), but has not been fully characterized and therefore, its effect on Abl1 protein function is unknown. |
Technical Data | |
DNA Change | c.944C>T |
AA Change | p.T315I |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100.00% |
Transcript | NM_007313.2 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | -20°C |
Expiry | 36 months from the date of manufacture |